Mammalian cells require oxygen for their energy homeostasis. But cells in solid tumors may survive in hypoxic microenvironment, where oxygen supply is blocked or instable due to
abnormalities of the vascular networks. Such cells adapt to the chronic or intermittent hypoxic conditions through regulation of stress-responsive genes as well as energy metabolic
pathways of the cells.
This project aims to understand molecular mechanisms involved in regulation of gene expression and energy metabolism in hypoxic cells using gene-modified mouse and biochemical strategies.